Effectiveness and safety of vitamin B12 tests

In the last five years, the use of vitamin B12 tests has increased significantly in Switzerland, especially with regard to tests for vitamin B12, transcobalamin II and III, holotranscobalamin (holo-TC) and methylmalonic acid (MMS). The question of whether vitamin B12 testing is necessary in patients at risk of vitamin B12 deficiency and in patients with clinical suspicion of vitamin B12 deficiency before starting vitamin B12 supplementation was explored. The aim of this Health Technology Assessment (HTA) short report was to highlight the advantages and disadvantages associated with vitamin B12 testing in patients with clinically suspected or at high risk of vitamin min B12 deficiency.

Last modification 02.11.2021

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Federal Office of Public Health FOPH
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