Revascularisation versus optimal medical therapy for the treatment of chronic coronary syndrome

Patients with chronic coronary syndrome (CCS) may be treated with conservative methods, including optimal medical therapy (OMT) and risk factor modifications (e.g. lifestyle modifications, etc.), with or without invasive interventions. Revascularisation is an invasive intervention in which patients undergo percutaneous coronary intervention (PCI) – also known as percutaneous transluminal coronary angioplasty – or coronary artery bypass grafting (CABG). These interventions aim to improve quality of life and reduce mortality. Revascularisation are well established as standard practice in patients with acute coronary syndromes (ACS). However, controversies regarding their implementation in CCS patients remain.

The aim of the HTA is to evaluate the evidence regarding efficacy, effectiveness, and safety of PCI with OMT and CABG with OMT compared to OMT alone. The proposed HTA will also involve an economic evaluation of the intervention and comparator. Additionally, ethical, legal, social and organisational issues are to be explored.

Last modification 05.08.2022

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