Health technology assessment reports

Below is a list of HTA reports that have been completed.

Dual Antiplatelet Therapy following Percutaneous Coronary Intervention

This report presents a summary of a health technology assessment (HTA) report published by the Canadian Agency for Drugs and Technologies in Health that evaluated the evidence pertaining to the comparative clinical efficacy and safety of six to 12 months dual antiplatelet therapy (DAPT) versus extended DAPT (>12 months), following percutaneous coronary intervention with stent insertion in coronary artery disease patients and various subpopulations.

Olmesartan Mono- and Combination Therapies in Patients with Essential Hypertension

The aim of the Health Technology Assessment (HTA) is to evaluate the efficacy, effectiveness, safety, cost-effectiveness and budget impact of olmesartan mono- and combination therapies compared to all other sartan mono- and combination therapies available in Switzerland in patients with essential hypertension.

Treatment of non-erosive gastroesophageal reflux disease patients with proton pump inhibitors

The aim of the Health Technology Assessment (HTA) is to evaluate the efficacy, effectiveness, safety, cost-effectiveness and budget impact of long-term continuous proton pump inhibitor (PPI) therapy compared to long-term on-demand PPI therapy in patients with non-erosive reflux disease (NERD) and patients with uninvestigated gastroesophageal reflux disease (GERD).

Glinides and glitazones in the treatment of type 2 diabetes

The aim of the short report is to assess the efficacy and safety of glinides and glitazones in treating patients with type 2 diabetes compared to all other non-insulin based antidiabetics available in Switzerland.

Iron Therapy for Iron Deficiency without Anaemia

The objective of this HTA was to,

  • assess the efficacy and safety of both oral and i.v. iron therapy in patients with symptomatic iron deficiency without anaemia in comparison to other therapies or placebo,
  • develop insights on specific symptoms and diagnostic markers that allow to define an iron deficiency needing treatment and to determine if particular subgroups of patients will benefit more than others from iron therapy,
  • assess the cost-effectiveness of oral vs. i.v. iron therapy for those indications where a treatment effect is being shown.

Chondroitin Sulfate in Osteoarthritis

The objective of the HTA is to compare the safety, efficacy and effectiveness of chondroitin sulfate with placebo, on-demand analgesics and anti-inflammatory treatments in patients with osteoarthritis of the hands, knees and hips. In addition, the cost-effectiveness and budgetary impact of chondroitin sulfate warrants investigation.

Self-measurement of blood glucose in patients with non-insulin treated diabetes mellitus type 2

Research questions:

  • What is the effect on HbA1c of self-measurement of blood glucose in patients with non-insulin treated diabetes mellitus type 2?
  • How does a decrease in HbA1c levels affect clinical endpoints?
  • What is the safety profile of self-measurement of blood glucose?
  • What is the cost-effectiveness of the different possible variations in self-measurement of blood glucose?

Knee arthroscopy for the treatment of degenerative changes

The aim of the report is

  • To systematically review the evidence on the clinical efficacy and safety of knee arthroscopy for treating degenerative changes in the knee (meniscus and neighbouring structures) compared with other, non-invasive forms of therapy
  • To assess the cost-effectiveness and calculate the budgetary impact of such procedures
  • To review the evidence on clinical efficacy and safety, and to compare the cost-effectiveness and budgetary impact of such procedures conducted on an inpatient versus an outpatient basis

Spinal procedures with specific types of implant in cases of therapy-resistant pain and/or neurological failure

The aim of the report is to systematically review the evidence on the clinical effectiveness and safety of disc prostheses in the cervical and lumbar spine and of interspinous or pedicle-based stabilisation in patients with degenerative changes of the lumbar spine either compared to direct decompression only or to fusion.

Last modification 13.11.2020

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Federal Office of Public Health FOPH
Division of Health Care Services
Health Technology Assessment Section
Schwarzenburgstrasse 157
3003 Berne
Switzerland
Tel. +41 58 469 17 33
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